We are excited to share that IMPC data has now been cited in over 8,000 peer-reviewed publications!
IMPC generated resources, including mouse products and data for over 9,073 mouse genes, are available to the scientific community for their own research and publications. As a global initiative, the International Mouse Phenotyping Consortium (IMPC) is dedicated to building a comprehensive resource for understanding gene function by systematically generating and analysing knockout mouse models and making these resources available to the scientific community.
The continued increase in the number of studies referencing IMPC reflects the impact of this resource on genetic research over the years. Researchers across various fields have used our resources to explore topics such as neuropsychiatric diseases and the genetics of human disorders. The consortium’s own publications not only further explore the data providing insights on rare diseases but also highlight the advancements and utilisation of new technologies, such as CRISPR.
In addition to our vast, publicly accessible phenotyping datasets and mouse products, IMPC provides additional training and collaboration opportunities to allow better understanding of and further research based on IMPC resources. Training courses, webinars and workshops are run regularly with recordings made available afterwards. These cover training on how to use the IMPC website and accessing the data as well as specialised workshops fostering collaborations and featuring guest speakers from around the world. These resources will soon be available in a more easily accessible location so watch this space! As the demand for high-quality genomic and phenotypic data continues to rise, IMPC remains committed to expanding its resource and collaborating with the global scientific community.
By generating mutant models and providing free and open access to our data, IMPC continues to drive progress in genetics and biomedical research, helping to uncover new insights into mammalian biology and disease.
To access the IMPC consortium publications and the publications with IMPC Data: https://www.mousephenotype.org/data/publications
References:
Pantiru, A.D., Van de Sompele, S., Ligneul, C. et al. Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice. Molecular Autism 16, 14 (2025). https://doi.org/10.1186/s13229-025-00650-8
Kasprzyk-Pawelec, A., Tan, M., Rahhal, R. et al. Inactivation of the SLC25A1 gene during embryogenesis induces a unique senescence program controlled by p53. Cell Death Differ (2024). https://doi.org/10.1038/s41418-024-01428-w
Martinez, S., Wu, S., Geuenich, M. et al. In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer. Nat Commun 15, 5266 (2024). https://doi.org/10.1038/s41467-024-49450-3
Hölter, S.M., Cacheiro, P., Smedley, D. et al. IMPC impact on preclinical mouse models. Mamm Genome (2025). https://doi.org/10.1007/s00335-025-10104-4