DSS Histology DSS_DSS_001

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Dextran Sodium Sulphate (DSS) Histology

Mutant mice and wild-type controls (2 female and 2 males/group)

Mutant mice and wild-type controls (2 female and 2 males/group) receive 1.5% dextran sodium sulphate (DSS) in drinking water for 7 days.

Weights are recorded daily and any mice that have lost greater than 20% or that exhibit clinical signs are sacrificed.

At day 10 mice are sacrificed and samples from the medial and distal gut are collected for histological analysis.

A pathology scoring system is used to assess the effect of the DSS in a blinded manner.

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