Help & Documentation

Which data does not go through the statistical pipeline?

The following phenotypes are assigned by experts: fertility, viability, embryo viability, embryo gross morphology, pathology, histopathology.

Viability:

  • Version 1: The mp_term is assigned based on the outcome (homozygous viable or homozygous lethal).
  • Version 2: The pipeline determines viability or lethality and assigns the mp_term based on the percentage of living and viable pups. 
  • The same process applies to embryo viability.

Embryo Gross Pathology:

  • If there are two or more specimens, the pipeline marks it as abnormal and significant. Specimens can be homozygous, hemizygous, or heterozygous.

Histopathology:

  • Experts provide a phenotype term with a significance score, 0 for not significant and 1 for significant. The CDA then identifies a significant association between the allele and the phenotype based on the tech expert’s opinion.

Pathology:

  • Experts indicate if the sample is normal or abnormal. If any sample analysed for a mutant line is recorded as abnormal, the CDA marks the allele as abnormal.