Histopathology data for Baz2a

Severity Score:

0 = Normal
1 = Mild (observation barely perceptible and not believed to have clinical significance)
2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical)
3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor)
4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.



Trachea	homozygote	#1	N/A	normal	0	0	N/A	N/A
Mammary gland	homozygote	#1	There is expansion of the lobules by a monomorphic...	hyperplasia	3	0	distributed chronic	Gynecomastia with atypical Lobular Hyperplasia.
Pituitary gland	homozygote	#1	N/A	normal	0	0	N/A	N/A
Spinal cord	homozygote	#1	N/A	normal	0	0	N/A	N/A
Tooth	homozygote	#1	N/A	normal	0	0	N/A	N/A
Eye	homozygote	#1	There is multifocal clusters of external nuclear s...	dysplasia	1	0	unilateral chronic	Retinal dysplasia
Optic II nerve	homozygote	#1	N/A	normal	0	0	N/A	N/A
Ovary	homozygote	#1	N/A	N/A	0	Not applicable	N/A	N/A
Testis	homozygote	#1	Multifocally, some of the seminiferous tubules are...	dysplasia	2	0	bilateral chronic	Testicular degeneration
Bone marrow	homozygote	#1	N/A	normal	0	0	N/A	N/A