Illuminating the Druggable Genome (IDG)
IDGis an NIH Common Fund project focused on collecting, integrating and making available biological data on 278 human genes from three key druggable protein families that have been identified as potential therapeutic targets: non-olfactory G-protein coupled receptors (GPCRs), ion channels, and protein kinases. The IMPC consortium is creating knockout mouse strains for the IDG project to better understand the function of these proteins.
IMPC data representation for IDG genes
IDG human genes are mapped to mouse orthologs using HCOP. The IMPC consortium is using different complementary targeting strategies to produce Knockout strains. Mice are produced and submitted to standardised phenotyping pipelines. Currently 63.7 % of mouse IDG gene have data representation in IMPC, the bar charts and heatmap below capture the IMPC data representation at different levels. The percentage might increase as we get more data and this page will reflect the change.
IMPC IDG data Heat Map
The heat map indicates the detailed IDG gene data representation in IMPC, from product availability to phenotypes. Phenotypes are grouped by biological systems.
Significant | Not Significant | No data |
Phenotype Associations
The following chord diagrams represent the various biological systems phenotype associations for IDG genes categorized both in all and in each family group. The line thickness is correlated with the strength of the association. Clicking on chosen phenotype(s) on the diagram allow to select common genes. Corresponding gene lists can be downloaded using the download icon.
All families
132 genes have phenotypes in more than one biological system. The chord diagram below shows the pleiotropy between these genes.
Get the genes and associated phenotypes.
Ion channels
| IMPC/IDG genes | 57 |
| ES Cells produced | 45 |
| Mice produced | 48 |
| Phenotypes | 40 |
32 genes have phenotypes in more than one biological system. The chord diagram below shows the pleiotropy between these genes.
Get the genes and associated phenotypes.
GPCRs
| IMPC/IDG genes | 97 |
| ES Cells produced | 58 |
| Mice produced | 61 |
| Phenotypes | 48 |
38 genes have phenotypes in more than one biological system. The chord diagram below shows the pleiotropy between these genes.
Get the genes and associated phenotypes.
Kinases
| IMPC/IDG genes | 121 |
| ES Cells produced | 97 |
| Mice produced | 78 |
| Phenotypes | 68 |
66 genes have phenotypes in more than one biological system. The chord diagram below shows the pleiotropy between these genes.
Get the genes and associated phenotypes.