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Phenotype: abnormal motor coordination/balance

Definition
altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium
Synonyms
impaired proprioception
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal motor coordination/balance

There was a problem retrieving some of the phenotype calls. Some rows migth be missing from the table below. Error code(s) #18.

Total number of significant genotype-phenotype associations: 76

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Ush1c
Ush1ctm1a(KOMP)Wtsi 		HOM Early adult impaired righting response Contact righting reflex
Combined SHIRPA and Dysmorphology		 WTSI
IMPC		 2.82×10-23
Lepr
Leprtm1b(EUCOMM)Wtsi 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 5.55×10-22
Mir96
Mir96tm3.2(IMPC)Wtsi 		HOM Early adult impaired righting response Contact righting reflex
Combined SHIRPA and Dysmorphology		 WTSI
IMPC		 8.76×10-21
Cyba
Cybatm1a(EUCOMM)Wtsi 		HOM Early adult impaired righting response Contact righting reflex
Combined SHIRPA and Dysmorphology		 WTSI
IMPC		 2.23×10-17
Cdh23
Cdh23tm2b(EUCOMM)Wtsi 		HOM Early adult impaired righting response Contact righting reflex
Combined SHIRPA and Dysmorphology		 WTSI
IMPC		 2.69×10-14
Kcne1
Kcne1tm1b(EUCOMM)Hmgu 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 ICS
IMPC		 2.96×10-11
Hsd17b1
Hsd17b1tm1.1(KOMP)Vlcg 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 3.26×10-11
Abcg8
Abcg8tm1b(KOMP)Wtsi 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 CCP-IMG
IMPC		 4.40×10-10
Pfdn6
Pfdn6tm1.1(KOMP)Vlcg 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 4.52×10-10
Myo7a
Myo7atm1a(EUCOMM)Wtsi 		HOM Early adult impaired righting response Contact righting reflex
Combined SHIRPA and Dysmorphology		 WTSI
IMPC		 1.38×10-08
Kcnj6
Kcnj6em1(IMPC)H 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 3.49×10-08
Dll1
Dll1tm1Gos 		HET Early adult abnormal righting response Contact Righting Reflex
Shirpa (GMC)		 HMGU
EuroPhenome		 4.09×10-08
Pkp4
Pkp4tm1b(EUCOMM)Wtsi 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 8.85×10-08
Tpo
Tpoem1(IMPC)H 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 1.07×10-07
Eef1b2
Eef1b2em1(IMPC)J 		HOM Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.74×10-07
Polr1c
Polr1cem1(IMPC)J 		HET Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.74×10-07
Hapln1
Hapln1tm1.1(KOMP)Mbp 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.76×10-07
Slc8b1
Slc8b1em1(IMPC)J 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.76×10-07
Igsf11
Igsf11tm1b(KOMP)Wtsi 		HOM Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.78×10-07
Srbd1
Srbd1em1(IMPC)J 		HET Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.78×10-07
Utp4
Utp4em1(IMPC)J 		HET Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.78×10-07
Hecw1
Hecw1tm2b(EUCOMM)Hmgu 		HOM Middle aged adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 2.46×10-07
Epgn
Epgntm1b(KOMP)Wtsi 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 3.14×10-07
Tent5a
Tent5aem1(IMPC)Ccpcz 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 CCP-IMG
IMPC		 5.87×10-07
Prss2
Prss2tm1.1(KOMP)Vlcg 		HOM Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 7.32×10-07
AU040320
AU040320em1(IMPC)J 		HOM Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 7.88×10-07
Yeats2
Yeats2em1(IMPC)J 		HET Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 7.88×10-07
Odf3l2
Odf3l2tm1.1(KOMP)Vlcg 		HET   Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 UC Davis
IMPC		 1.70×10-06
Cep43
Cep43tm1b(EUCOMM)Hmgu 		HET   Early adult abnormal motor coordination/balance Latency to fall_Mean
Rotarod		 HMGU
IMPC		 2.69×10-06
Rxylt1
Rxylt1em1(IMPC)J 		HET Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 3.16×10-06
Serpinb5
Serpinb5tm1b(KOMP)Wtsi 		HOM   Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 3.49×10-06
Avp
Avptm1b(EUCOMM)Wtsi 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 4.51×10-06
Fgf7
Fgf7tm1e.1(EUCOMM)Hmgu 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 4.51×10-06
Gnao1
Gnao1tm1b(EUCOMM)Hmgu 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 4.51×10-06
Mcub
Mcubtm1b(KOMP)Mbp 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 4.51×10-06
Myo1h
Myo1htm1b(KOMP)Wtsi 		HET Early adult abnormal motor coordination/balance Average duration
Rotarod		 JAX
IMPC		 4.98×10-06
Mfsd4b4
Mfsd4b4em1(IMPC)J 		HOM Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 5.08×10-06
Hsd17b1
Hsd17b1tm1.1(KOMP)Vlcg 		HOM Early adult abnormal motor coordination/balance Average duration
Rotarod		 JAX
IMPC		 5.28×10-06
Ky
Kyem1(IMPC)J 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 7.05×10-06
Slc20a2
Slc20a2tm1b(EUCOMM)Wtsi 		HET Early adult abnormal motor coordination/balance Latency to fall_Mean
Rotarod		 HMGU
IMPC		 8.23×10-06
Epha10
Epha10tm1.1(KOMP)Vlcg 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.11×10-05
Stat1
Stat1tm2b(EUCOMM)Wtsi 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 ICS
IMPC		 1.12×10-05
Cdh4
Cdh4tm1b(EUCOMM)Wtsi 		HOM   Early adult abnormal motor coordination/balance Average duration
Rotarod		 JAX
IMPC		 1.17×10-05
Trf
Trfem1(IMPC)J 		HET Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.61×10-05
Samm50
Samm50em1(IMPC)Hmgu 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 HMGU
IMPC		 1.72×10-05
Ipp
Ipptm1.1(KOMP)Vlcg 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.77×10-05
Rnf25
Rnf25tm1.1(KOMP)Vlcg 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.77×10-05
Mir96
Mir96tm2.2(IMPC)Wtsi 		HOM Early adult impaired righting response Contact righting reflex
Combined SHIRPA and Dysmorphology		 WTSI
IMPC		 1.78×10-05
Inhbb
Inhbbtm1b(EUCOMM)Hmgu 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 2.19×10-05
Cers5
Cers5tm2b(KOMP)Mbp 		HOM Early adult abnormal motor coordination/balance Average duration
Rotarod		 JAX
IMPC		 2.34×10-05
Syn3
Syn3tm1.1(KOMP)Vlcg 		HOM Early adult abnormal motor coordination/balance Average duration
Rotarod		 JAX
IMPC		 2.64×10-05
Rap2b
Rap2btm1.1(KOMP)Vlcg 		HOM   Early adult abnormal motor coordination/balance Average duration
Rotarod		 JAX
IMPC		 2.90×10-05
Svop
Svopem1(IMPC)H 		HOM Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 3.13×10-05
Klf7
Klf7tm1b(EUCOMM)Hmgu 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 4.66×10-05
Fastkd5
Fastkd5em1(IMPC)J 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 4.66×10-05
Zfp689
Zfp689tm1.1(KOMP)Vlcg 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 4.66×10-05
Jmjd6
Jmjd6tm1b(EUCOMM)Wtsi 		HET   Early adult abnormal motor coordination/balance Latency to fall_Mean
Rotarod		 HMGU
IMPC		 4.92×10-05
Cep170b
Cep170bem1(IMPC)Hmgu 		HOM   Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 HMGU
IMPC		 6.07×10-05
Pitx3
Pitx3tm1.1(KOMP)Vlcg 		HOM Early adult abnormal motor coordination/balance Average duration
Rotarod		 JAX
IMPC		 7.94×10-05
Grm7
Grm7em1(IMPC)H 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 9.38×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Combined SHIRPA and Dysmorphology
Click-box
Modified SHIRPA
Rotarod
Rotarod A (GMC)
Rotarod B (GMC)
SHIRPA
Shirpa (GMC)

 Phenotype associations stats

0.85% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal motor coordination/balance (59/6943)

0.71% females (37/5247) 0.61% males (32/5251)

Select a parameter    



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