Runx2 | runt related transcription factor 2

GeneMGI:99829Synonyms: Osf2, Pebpa2a, +6 more

Physiological systems

14 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Growth/size/body region Limbs/digits/tail Skeleton Craniofacial

10 No significant impact

10 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal pelvic girdle bone morphology	1 supporting dataset	Runx2^{em1(IMPC)Rbrc}	heterozygote	Early adult	4.67x10^-6
abnormal humerus morphology	1 supporting dataset	Runx2^{em1(IMPC)Rbrc}	heterozygote	Early adult	1.97x10^-8
abnormal clavicle morphology	1 supporting dataset	Runx2^{em1(IMPC)Rbrc}	heterozygote	Early adult	6.97x10^-11
increased lean body mass	1 supporting dataset	Runx2^{em1(IMPC)Rbrc}	heterozygote	Early adult	4.39x10^-5
abnormal bone structure	1 supporting dataset	Runx2^{em1(IMPC)Rbrc}	heterozygote	Early adult	3.17x10^-5
abnormal cranium morphology	1 supporting dataset	Runx2^{em1(IMPC)Rbrc}	heterozygote	Early adult	4.18x10^-10
abnormal zygomatic bone morphology	1 supporting dataset	Runx2^{em1(IMPC)Rbrc}	heterozygote	Early adult	6.97x10^-11
abnormal vertebral arch morphology	2 supporting datasets	Runx2^{em1(IMPC)Rbrc}	heterozygote	Early adult	3.02x10^-6
decreased bone mineral content	1 supporting dataset	Runx2^{em1(IMPC)Rbrc}	heterozygote	Early adult	5.95x10^-8
abnormal vertebrae morphology	1 supporting dataset	Runx2^{em1(IMPC)Rbrc}	heterozygote	Early adult	8.79x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Runx2.

Associated images

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Histopathology

There is no histopathology data found for Runx2.

IMPC related publications

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External links

No external links available for Runx2.

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*Runx2^{em1(IMPC)Rbrc}*	Exon Deletion	‌	mouse
*Runx2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Runx2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes