Clock | clock circadian regulator

GeneMGI:99698Synonyms: KAT13D, bHLHe8, +1 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Endocrine/exocrine gland Growth/size/body region Respiratory system Hematopoietic system Skeleton Craniofacial Cardiovascular system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased red blood cell distribution width	1 supporting dataset	Clock^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.21x10^-6
increased T-helper cell number	1 supporting dataset	Clock^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.68x10^-9
increased lung elastance	3 supporting datasets	Clock^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.12x10^-6
enlarged thymus	1 supporting dataset	Clock^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal inspiratory capacity	1 supporting dataset	Clock^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.39x10^-7
increased CD4-positive, alpha-beta T cell number	1 supporting dataset	Clock^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.45x10^-9
abnormal tooth morphology	1 supporting dataset	Clock^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased eosinophil cell number	1 supporting dataset	Clock^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.1x10^-7
abnormal skin morphology	2 supporting datasets	Clock^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating triglyceride level	1 supporting dataset	Clock^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.44x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Clock.

Associated images

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Histopathology

There is no histopathology data found for Clock.

IMPC related publications

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External links

No external links available for Clock.

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*Clock^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Clock^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell

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