Adcy1 | adenylate cyclase 1

GeneMGI:99677Synonyms: AC1, I-AC, +1 more

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Immune system Integument Hematopoietic system Behavior/neurological

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:

Life Stage:



hyperactivity	5 supporting datasets	Adcy1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	1.53x10^-20
abnormal coat/hair pigmentation	1 supporting dataset	Adcy1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	8.02x10^-6
hyperactivity	7 supporting datasets	Adcy1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.64x10^-7
increased leukocyte cell number	1 supporting dataset	Adcy1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.14x10^-6
abnormal coat/hair pigmentation	1 supporting dataset	Adcy1^{tm1b(EUCOMM)Wtsi}	homozygote	Middle aged adult	3.41x10^-5
improved glucose tolerance	1 supporting dataset	Adcy1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.86x10^-5
increased circulating creatine kinase level	1 supporting dataset	Adcy1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	1.86x10^-59
abnormal locomotor behavior	1 supporting dataset	Adcy1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	4.86x10^-5
increased mean corpuscular volume	1 supporting dataset	Adcy1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.99x10^-5
increased circulating phosphate level	1 supporting dataset	Adcy1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	1.01x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Adcy1.

Associated images

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Histopathology

There is no histopathology data found for Adcy1.

IMPC related publications

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External links

No external links available for Adcy1.

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*Adcy1^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Adcy1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Adcy1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Adcy1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Adcy1^{tm2(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell

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