Ryr1 | ryanodine receptor 1, skeletal muscle

GeneMGI:99659Synonyms: calcium release channel isoform 1, skrr, +1 more

Physiological systems

16 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Mortality/aging

11 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

15Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased respiratory quotient	1 supporting dataset	Ryr1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.74x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Ryr1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased spleen weight	1 supporting dataset	Ryr1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.61x10^-15

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ryr1.

Associated images

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Histopathology

There is no histopathology data found for Ryr1.

IMPC related publications

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External links

No external links available for Ryr1.

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*Ryr1^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Ryr1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ryr1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ryr1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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