banner
Genes Phenotypes Help, News, Blog

Gene: Cd63 MGI:99529

Log in to follow
Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
CD63 antigen
Synonyms:
Tspan30,  ME491

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cd63 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cd63 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Renal Glucosuria
Enuresis nocturna, Polydipsia, Glycosuria, Polyphagia, Polyuria OMIM:233100
Senior-Loken Syndrome 4
Stage 5 chronic kidney disease, Nephronophthisis, Polydipsia, Polyuria OMIM:606996
Nephronophthisis-Like Nephropathy 2
Polydipsia, Stage 5 chronic kidney disease, Renal insufficiency, Polyuria, Tubular luminal dilata... OMIM:619468
Pentosuria
Abnormality of urine homeostasis OMIM:260800
Nephronophthisis 9
Nephronophthisis, Polydipsia, Stage 5 chronic kidney disease, Polyuria, Renal cortical microcysts OMIM:613824
Type 1 Diabetes Mellitus
Polyphagia, Polydipsia, Polyuria OMIM:222100
Renal Hypoplasia
Chronic kidney disease, Unilateral renal agenesis, Polydipsia, Glomerulomegaly, Recurrent urinary... ORPHA:93101
Ochoa Syndrome
Urethral obstruction, Polydipsia, Recurrent urinary tract infections, Vesicoureteral reflux, Rena... ORPHA:2704
Nephronophthisis 1
Nephronophthisis, Tubular basement membrane disintegration, Polydipsia, Stage 5 chronic kidney di... OMIM:256100
Nephronophthisis 3
Nephronophthisis, Polydipsia, Stage 5 chronic kidney disease, Renal insufficiency, Proteinuria, R... OMIM:604387
Hypercalcemia, Infantile, 1
Nephrocalcinosis, Vomiting, Medullary nephrocalcinosis, Nephrolithiasis, Hypercalciuria, Polyuria... OMIM:143880
Nephronophthisis 4
Nephronophthisis, Polydipsia, Stage 5 chronic kidney disease, Renal corticomedullary cysts, Tubul... OMIM:606966
Central Diabetes Insipidus
Diarrhea, Polydipsia, Nocturia, Anorexia, Dehydration ORPHA:178029
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Vomiting, Polydipsia, Megacystis, Constipation, Polyuria, Hypertonic dehydration OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Vomiting, Polydipsia, Megacystis, Constipation, Polyuria, Hypertonic dehydration OMIM:304800
Nephrogenic Diabetes Insipidus
Enuresis nocturna, Functional abnormality of the bladder, Hydroureter, Polydipsia, Hypernatremic ... ORPHA:223
Hypercalcemia, Infantile, 2
Renal phosphate wasting, Nephrocalcinosis, Medullary nephrocalcinosis, Hypercalciuria, Polyuria OMIM:616963
Senior-Loken Syndrome 3
Nephronophthisis, Polydipsia, Stage 5 chronic kidney disease, Renal corticomedullary cysts, Polyu... OMIM:606995
Senior-Loken Syndrome 1
Nephronophthisis, Polydipsia, Stage 5 chronic kidney disease, Renal insufficiency, Impaired renal... OMIM:266900
Hypomagnesemia, Seizures, And Impaired Intellectual Development 2
Nephrocalcinosis, Renal magnesium wasting, Hyperactivity, Polyuria, Self-biting, Renal potassium ... OMIM:618314
Acquired Central Diabetes Insipidus
Polydipsia, Pollakisuria ORPHA:95626
Teratoma, Pineal
Polydipsia, Polyuria OMIM:273120
Cystinosis
Nephropathy, Aminoaciduria, Vomiting, Polydipsia, Renal insufficiency, Renal tubular dysfunction,... ORPHA:213
Nephronophthisis 11
Tubular basement membrane disintegration, Nephronophthisis, Polydipsia, Stage 5 chronic kidney di... OMIM:613550
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Hyperchloriduria, Polydipsia, Hypernatriuria, Decreased glomerular filtration rate, Reduced renal... OMIM:602522
Hyperaldosteronism, Familial, Type Iii
Hypercalciuria, Polydipsia, Polyuria OMIM:613677
Oligomeganephronia
Unilateral renal agenesis, Abnormal nephron morphology, Polydipsia, Glomerulomegaly, Bilateral re... ORPHA:2260
Helix Syndrome
Hypocalciuria, Polydipsia, Xerostomia, Renal insufficiency, Nephrolithiasis, Polyuria OMIM:617671
Hereditary Central Diabetes Insipidus
Diarrhea, Vomiting, Polydipsia ORPHA:30925
Distal Renal Tubular Acidosis
Aminoaciduria, Nephrocalcinosis, Proximal tubulopathy, Polydipsia, Diarrhea, Vomiting, Low-molecu... ORPHA:18
East Syndrome
Polydipsia, Abnormal urinary electrolyte concentration, Renal magnesium wasting, Renal sodium was... ORPHA:199343
Kleine-Levin Syndrome
Polydipsia, Abnormal eating behavior, Sweet craving, Polyphagia, Repetitive compulsive behavior, ... ORPHA:33543
Bartter Syndrome, Type 4B, Neonatal, With Sensorineural Deafness
Hyperchloriduria, Hypernatriuria, Decreased glomerular filtration rate, Renal insufficiency, Incr... OMIM:613090
Senior-Boichis Syndrome
Chronic kidney disease, Renal hypoplasia, Polydipsia, Abnormal urinary electrolyte concentration,... ORPHA:84081
Adenine Phosphoribosyltransferase Deficiency
Oliguria, Urolithiasis, Renal insufficiency, 2,8-dihydroxyadenine crystalluria, Nephrolithiasis, ... OMIM:614723
Bartter Syndrome, Type 3
Nephrocalcinosis, Hyperchloriduria, Hypocalciuria, Increased urinary potassium, Impaired renal tu... OMIM:607364
Idiopathic Steroid-Resistant Nephrotic Syndrome
Focal segmental glomerulosclerosis, Minimal change glomerulonephritis, Acute kidney injury, Stage... ORPHA:567548
Adenine Phosphoribosyltransferase Deficiency
Chronic kidney disease, Acute kidney injury, Oliguria, Urinary retention, Recurrent urinary tract... ORPHA:976
Proximal Renal Tubular Acidosis
Aminoaciduria, Nephrocalcinosis, Diarrhea, Polydipsia, Glycosuria, Hypernatriuria, Vomiting, Low-... ORPHA:47159
Bartter Syndrome, Type 5, Antenatal, Transient
Polyhydramnios, Medullary nephrocalcinosis, Hypercalciuria, Polyuria OMIM:300971
Bardet-Biedl Syndrome 9
Polyphagia, Polydipsia, Renal insufficiency OMIM:615986
Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia
Diarrhea, Vomiting, Proximal tubulopathy, Polyuria, Dehydration OMIM:560000
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Hypocalciuria, Enuresis, Polydipsia, Renal sodium wasting, Salt craving, Polyuria, Renal salt was... OMIM:612780
Juvenile Nephropathic Cystinosis
Renal phosphate wasting, Chronic kidney disease, Aminoaciduria, Proximal tubulopathy, Polydipsia,... ORPHA:411634
Infantile Nephropathic Cystinosis
Aminoaciduria, Vomiting, Polydipsia, Glycosuria, Low-molecular-weight proteinuria, Hyperphosphatu... ORPHA:411629
Hyperparathyroidism, Neonatal Severe
Aminoaciduria, Polydipsia, Hyperphosphaturia, Hypercalciuria, Constipation, Polyuria OMIM:239200
Bardet-Biedl Syndrome 17
Polydipsia, Stage 5 chronic kidney disease, Renal cyst, Polyuria, Micropenis OMIM:615994
Apparent Mineralocorticoid Excess
Abnormal urine sodium concentration, Nephrocalcinosis, Renal insufficiency, Polydipsia ORPHA:320
Familial Hyperaldosteronism Type Iii
Nausea, Hypercalciuria, Polydipsia ORPHA:251274
Gitelman Syndrome
Hypocalciuria, Enuresis, Renal magnesium wasting, Polydipsia, Vomiting, Salt craving, Constipatio... OMIM:263800
Familial Cold Urticaria
Polydipsia, Dehydration ORPHA:47045
Hypomagnesemia 3, Renal
Chronic kidney disease, Hematuria, Macroscopic hematuria, Polydipsia, Sterile pyuria, Renal magne... OMIM:248250
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3
Polydipsia, Polyuria, Nephrolithiasis OMIM:617994
Primary Unilateral Adrenal Hyperplasia
Nausea, Polydipsia, Increased urinary potassium ORPHA:231580
Bartter Syndrome, Type 2, Antenatal
Nephrocalcinosis, Hyperchloriduria, Renal juxtaglomerular cell hypertrophy/hyperplasia, Polydipsi... OMIM:241200
Hypouricemia, Renal, 1
Acute kidney injury, Oliguria, Renal cortical hyperechogenicity, Urolithiasis, Proteinuria, Hyper... OMIM:220150
Amelogenesis Imperfecta, Type Ig
Nephrocalcinosis, Renal insufficiency, Impaired renal concentrating ability, Polyuria, Enuresis OMIM:204690
Hypomagnesemia 7, Renal, With Or Without Dilated Cardiomyopathy
Nephrocalcinosis, Polyuria OMIM:620152
Hyperuricemia, Pulmonary Hypertension, Renal Failure, And Alkalosis Syndrome
Chronic kidney disease, Hyperechogenic kidneys, Proteinuria, Polyuria, Renal salt wasting OMIM:613845
Proteinuria, Low Molecular Weight, With Hypercalciuria And Nephrocalcinosis
Focal segmental glomerulosclerosis, Aminoaciduria, Nephrocalcinosis, Proximal tubulopathy, Glycos... OMIM:308990
Bartter Syndrome, Type 1, Antenatal
Nephrocalcinosis, Hyperchloriduria, Renal juxtaglomerular cell hypertrophy/hyperplasia, Diarrhea,... OMIM:601678
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Acute kidney injury, Multicystic kidney dysplasia, Polydipsia, Renal agenesis, Horseshoe kidney, ... ORPHA:93111
Cystinosis, Nephropathic
Aminoaciduria, Generalized aminoaciduria, Polydipsia, Glycosuria, Exocrine pancreatic insufficien... OMIM:219800
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Nausea, Polydipsia, Nephrolithiasis ORPHA:369929
Diarrhea 10, Protein-Losing Enteropathy Type
Hematochezia, Secretory diarrhea, Anasarca, Ascites, Pleural effusion, Polyuria, Polyhydramnios, ... OMIM:618183
Arima Syndrome
Nephronophthisis, Polydipsia, Stage 5 chronic kidney disease, Renal sodium wasting, Hematuria, Pr... OMIM:243910
Renal Hypoplasia, Bilateral
Chronic kidney disease, Renal hypoplasia, Oliguria, Beta 2-microglobulinuria, Glycosuria, Decreas... ORPHA:97362
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 5
Acute kidney injury, Anuria, Stage 5 chronic kidney disease, Proteinuria, Hematuria, Hemolytic-ur... OMIM:612925
Hyperparathyroidism-Jaw Tumor Syndrome
Nephrocalcinosis, Polydipsia, Renal hamartoma, Renal insufficiency, Nephroblastoma, Nephrolithias... ORPHA:99880
Familial Hyperaldosteronism Type I
Nausea, Polydipsia ORPHA:403
Parathyroid Carcinoma
Nephrocalcinosis, Polydipsia, Renal hamartoma, Renal insufficiency, Nephroblastoma, Nephrolithias... ORPHA:143
Pediatric-Onset Graves Disease
Diarrhea, Polydipsia, Oligohydramnios, Polyphagia, Hyperactivity ORPHA:525731
Primary Hyperoxaluria Type 3
Nephrocalcinosis, Abnormal renal physiology, Hyperoxaluria, Hematuria, Abnormality of urine homeo... ORPHA:93600
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 4
Acute kidney injury, Anuria, Proteinuria, Hematuria, Hemolytic-uremic syndrome OMIM:612924
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 3
Acute kidney injury, Anuria, Proteinuria, Hematuria, Hemolytic-uremic syndrome OMIM:612923
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 2
Acute kidney injury, Anuria, Proteinuria, Hematuria, Hemolytic-uremic syndrome OMIM:612922
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6
Acute kidney injury, Anuria, Proteinuria, Hematuria, Hemolytic-uremic syndrome OMIM:612926
Wolfram Syndrome
Nephropathy, Gastrointestinal hemorrhage, Abnormality of the urinary system, Polydipsia, Recurren... ORPHA:3463
Renal Tubular Dysgenesis
Renotubular dysgenesis, Oligohydramnios, Abnormality of the urinary system, Anuria OMIM:267430
Septo-Optic Dysplasia Spectrum
Hypoplasia of penis, Constipation, Polydipsia ORPHA:3157
Systemic Capillary Leak Syndrome
Oliguria, Diarrhea, Renal insufficiency, Pleural effusion, Pulmonary edema, Abnormal renal tubule... ORPHA:188
Erdheim-Chester Disease
Polydipsia, Pleural effusion, Renal insufficiency, Joint swelling, Hydronephrosis, Dysuria ORPHA:35687
Panhypophysitis
Nausea, Polydipsia, Hyposthenuria ORPHA:95513
Whipple Disease
Gastrointestinal hemorrhage, Diarrhea, Polydipsia, Anorexia, Pedal edema ORPHA:3452
Gitelman Syndrome
Focal segmental glomerulosclerosis, Enuresis, Polydipsia, Diarrhea, Pericardial effusion, Renal t... ORPHA:358
Toxic Epidermal Necrolysis
Gastrointestinal hemorrhage, Polydipsia, Abnormality of the urethra, Renal insufficiency, Dysphag... ORPHA:537
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Impaired renal uric acid clearance, Renal hypoplasia, Tubular basement membrane disintegration, D... OMIM:174000
Autosomal Recessive Polycystic Kidney Disease
Acute kidney injury, Oliguria, Polydipsia, Gastrointestinal hemorrhage, Recurrent urinary tract i... ORPHA:731
Mild Phosphoribosylpyrophosphate Synthetase Superactivity
Acute kidney injury, Stage 4 chronic kidney disease, Renal insufficiency, Hyperuricosuria, Uric a... ORPHA:411536
Car T Cell Therapy-Associated Cytokine Release Syndrome
Acute kidney injury, Diarrhea, Vomiting, Pleural effusion, Pulmonary edema, Decreased urine outpu... ORPHA:542323
Lassa Fever
Facial edema, Diarrhea, Oliguria, Dysphagia ORPHA:99824
Genetic Recurrent Myoglobinuria
Acute kidney injury, Oliguria, Exercise-induced myoglobinuria, Dark urine, Renal insufficiency, R... ORPHA:99845
Hemorrhagic Fever-Renal Syndrome
Chronic kidney disease, Acute kidney injury, Oliguria, Diarrhea, Anuria, Vomiting, Decreased glom... ORPHA:340
Rabson-Mendenhall Syndrome
Nephrocalcinosis, Long penis, Polydipsia ORPHA:769
Diffuse Cutaneous Systemic Sclerosis
Oliguria, Xerostomia, Gastroesophageal reflux, Renal insufficiency, Dysphagia ORPHA:220393
Acute Monoblastic/Monocytic Leukemia
Periorbital edema, Oliguria, Anorexia ORPHA:514
Ethylene Glycol Poisoning
Vomiting, Renal insufficiency, Renal tubular dysfunction, Hematuria, Pulmonary edema, Addictive a... ORPHA:31826
Duplication Of Urethra
Anuria, Recurrent urinary tract infections, Dysuria, Rectourethral fistula, Distal urethral dupli... ORPHA:237
Cholera
Acute kidney injury, Diarrhea, Vomiting, Decreased urine output, Abnormality of renal excretion, ... ORPHA:173
Lujo Hemorrhagic Fever
Facial edema, Generalized edema, Oliguria, Diarrhea, Vomiting, Renal insufficiency, Nausea, Dysph... ORPHA:319213
Pituitary Dermoid And Epidermoid Cysts
Polydipsia ORPHA:91351
Infection-Related Hemolytic Uremic Syndrome
Generalized edema, Acute kidney injury, Oliguria, Diarrhea, Anuria, Edema, Vomiting, Acute coliti... ORPHA:544482
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Self-injurious behavior, Polydipsia, Polyphagia, Aggressive behavior, Compulsive behaviors, Enuresis ORPHA:293987
Microscopic Polyangiitis
Gastrointestinal hemorrhage, Diarrhea, Oliguria, Renal insufficiency, Hematuria, Glomerulopathy, ... ORPHA:727
Aneurysm Of Sinus Of Valsalva
Oliguria, Edema ORPHA:1054
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Acute kidney injury, Diarrhea, Vomiting, Anuria, Acute colitis, Peritonitis, Hemoglobinuria, Bloo... ORPHA:90038
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Renal cortical hyperechogenicity, Anuria, Megacystis, Pyelonephritis, Oligohydramnios, Peritoniti... OMIM:619351
Colchicine Poisoning
Diarrhea, Vomiting, Oliguria, Renal insufficiency, Nausea, Dehydration ORPHA:31824
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Acute kidney injury, Diarrhea, Anuria, Hemolytic-uremic syndrome OMIM:235400
Lipodystrophy, Familial Partial, Type 7
Vomiting, Diarrhea, Pleural effusion, Polyuria, Dysphagia OMIM:606721
Zttk Syndrome
Horseshoe kidney, Unilateral renal agenesis, Chronic diarrhea, Polyuria OMIM:617140
Sepsis In Premature Infants
Diarrhea, Oliguria, Vomiting, Reversible renal failure, Enterocolitis, Edema ORPHA:90051
Brain-Lung-Thyroid Syndrome
Megacystis, Abnormal eating behavior, Vesicoureteral reflux, Abnormal drinking behavior, Hyperact... ORPHA:209905
Carnitine-Acylcarnitine Translocase Deficiency
Oliguria, Dicarboxylic aciduria ORPHA:159
Tumoral Calcinosis, Hyperphosphatemic, Familial, 1
Decreased renal tubular phosphate excretion, Increased renal tubular phosphate reabsorption, Neph... OMIM:211900
Cardiogenic Shock
Oliguria, Edema ORPHA:97292
Autosomal Recessive Hypophosphatemic Rickets
Renal phosphate wasting, Abnormality of renal excretion, Hyperphosphaturia ORPHA:289176
Yellow Fever
Acute kidney injury, Vomiting, Diarrhea, Anuria, Renal insufficiency, Hematemesis, Nausea ORPHA:99829
Exercise-Induced Malignant Hyperthermia
Vomiting, Acute kidney injury, Oliguria, Nausea ORPHA:466650

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cd63

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cd63.

No publications found that use IMPC mice or data for Cd63.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cd63tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cd63tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cd63tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Cd63tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter