Brd2 | bromodomain containing 2

GeneMGI:99495Synonyms: Rnf3, Frg-1, +3 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Immune system Hearing/vestibular/ear Hematopoietic system Skeleton Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Brd2^{em1(IMPC)Wtsi}	homozygote	Early adult	N/A ^*
abnormal auditory brainstem response	1 supporting dataset	Brd2^{em1(IMPC)Wtsi}	heterozygote	Early adult	1.15x10^-8
increased mean corpuscular hemoglobin	1 supporting dataset	Brd2^{em1(IMPC)Wtsi}	heterozygote	Early adult	1.86x10^-6
abnormal vertebral arch morphology	1 supporting dataset	Brd2^{em1(IMPC)Wtsi}	heterozygote	Early adult	4.06x10^-6
increased CD4-positive, alpha-beta T cell number	1 supporting dataset	Brd2^{em1(IMPC)Wtsi}	heterozygote	Early adult	N/A ^*
decreased CD8-positive, alpha-beta T cell number	1 supporting dataset	Brd2^{em1(IMPC)Wtsi}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Brd2.

Associated images

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Histopathology

There is no histopathology data found for Brd2.

IMPC related publications

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External links

No external links available for Brd2.

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*Brd2^{em1(IMPC)Wtsi}*	Deletion	‌	mouse
*Brd2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Brd2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Brd2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Brd2^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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