Notch3 | notch 3

GeneMGI:99460Synonyms: hpbk, N3

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Nervous system Liver/biliary system Hematopoietic system Cardiovascular system Renal/urinary system

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

6Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased neutrophil cell number	2 supporting datasets	Notch3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.19x10^-6
increased spleen weight	1 supporting dataset	Notch3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.04x10^-5
decreased liver weight	1 supporting dataset	Notch3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.94x10^-5
increased red blood cell distribution width	1 supporting dataset	Notch3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.07x10^-5
improved glucose tolerance	2 supporting datasets	Notch3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.66x10^-11
increased heart weight	1 supporting dataset	Notch3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.18x10^-5
decreased prepulse inhibition	1 supporting dataset	Notch3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.55x10^-5
abnormal kidney morphology	1 supporting dataset	Notch3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
enlarged kidney	1 supporting dataset	Notch3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased kidney weight	1 supporting dataset	Notch3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.22x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Notch3.

Associated images

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Histopathology

There is no histopathology data found for Notch3.

IMPC related publications

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External links

No external links available for Notch3.

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*Notch3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Notch3^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Notch3^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Notch3^{tm48394(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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