Adora2a | adenosine A2a receptor

GeneMGI:99402Synonyms: A2AAR, ARA2A, +3 more

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



increased circulating alanine transaminase level	1 supporting dataset	Adora2a^em1(IMPC)H	homozygote	Late adult	3.26x10^-27
increased circulating aspartate transaminase level	1 supporting dataset	Adora2a^em1(IMPC)H	homozygote	Late adult	5.89x10^-13
increased freezing behavior	1 supporting dataset	Adora2a^em1(IMPC)H	homozygote	Late adult	1.8x10^-6
decreased lean body mass	2 supporting datasets	Adora2a^em1(IMPC)H	homozygote	Late adult	3.98x10^-8
increased total body fat amount	2 supporting datasets	Adora2a^em1(IMPC)H	homozygote	Late adult	2.62x10^-8
decreased lymphocyte cell number	1 supporting dataset	Adora2a^em1(IMPC)H	homozygote	Late adult	1.21x10^-5
decreased locomotor activity	1 supporting dataset	Adora2a^em1(IMPC)H	homozygote	Early adult	5.39x10^-5
increased circulating glucose level	1 supporting dataset	Adora2a^em1(IMPC)H	homozygote	Early adult	5.26x10^-5
decreased lean body mass	1 supporting dataset	Adora2a^em1(IMPC)H	homozygote	Early adult	5.56x10^-5
decreased hemoglobin content	1 supporting dataset	Adora2a^em1(IMPC)H	homozygote	Late adult	8.99x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Adora2a.

Associated images

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Histopathology

There is no histopathology data found for Adora2a.

IMPC related publications

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External links

No external links available for Adora2a.

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*Adora2a^em1(IMPC)H*	Exon Deletion	‌	mouse
*Adora2a^em2(IMPC)H*	Exon Deletion	‌	mouse
*Adora2a^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Adora2a^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Adora2a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Adora2a^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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