Wnt3a | wingless-type MMTV integration site family, member 3A

GeneMGI:98956Synonyms: Wnt-3a

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Vision/eye Hematopoietic system Skeleton Cardiovascular system

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal retina vasculature morphology	1 supporting dataset	Wnt3a^{em1(IMPC)Ccpcz}	heterozygote	Early adult	1.37x10^-5
rib fusion	1 supporting dataset	Wnt3a^{em1(IMPC)Ccpcz}	heterozygote	Early adult	4.7x10^-11
abnormal vertebral arch morphology	3 supporting datasets	Wnt3a^{em1(IMPC)Ccpcz}	heterozygote	Early adult	4.07x10^-6
abnormal rib morphology	1 supporting dataset	Wnt3a^{em1(IMPC)Ccpcz}	heterozygote	Early adult	1.45x10^-10
abnormal coat appearance	1 supporting dataset	Wnt3a^{em1(IMPC)Ccpcz}	heterozygote	Early adult	2.84x10^-6
abnormal spleen morphology	2 supporting datasets	Wnt3a^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Wnt3a^{em1(IMPC)Ccpcz}	heterozygote	Early adult	4.53x10^-5
enlarged heart	1 supporting dataset	Wnt3a^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
increased circulating triglyceride level	1 supporting dataset	Wnt3a^{em1(IMPC)Ccpcz}	heterozygote	Early adult	6.31x10^-6
abnormal vertebrae morphology	1 supporting dataset	Wnt3a^{em1(IMPC)Ccpcz}	heterozygote	Early adult	3.78x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Wnt3a.

Associated images

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Histopathology

There is no histopathology data found for Wnt3a.

IMPC related publications

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External links

No external links available for Wnt3a.

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*Wnt3a^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Wnt3a^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Wnt3a^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Wnt3a^{tm286(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Wnt3a^{tm286(L1L2_st2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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