Wnt3a | wingless-type MMTV integration site family, member 3A
Physiological systems
21 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Integument Growth/size/body region Vision/eye Hematopoietic system Skeleton Cardiovascular system
13 No significant impact
3 Not tested
Data collections
Gene metrics:14Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal retina vasculature morphology | 1 supporting dataset | Wnt3aem1(IMPC)Ccpcz | heterozygote | Early adult | 1.37x10-5 | ||
| rib fusion | 1 supporting dataset | Wnt3aem1(IMPC)Ccpcz | heterozygote | Early adult | 4.7x10-11 | ||
| abnormal vertebral arch morphology | 3 supporting datasets | Wnt3aem1(IMPC)Ccpcz | heterozygote | Early adult | 4.07x10-6 | ||
| abnormal rib morphology | 1 supporting dataset | Wnt3aem1(IMPC)Ccpcz | heterozygote | Early adult | 1.45x10-10 | ||
| abnormal coat appearance | 1 supporting dataset | Wnt3aem1(IMPC)Ccpcz | heterozygote | Early adult | 2.84x10-6 | ||
| abnormal spleen morphology | 2 supporting datasets | Wnt3aem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Wnt3aem1(IMPC)Ccpcz | heterozygote | Early adult | 4.53x10-5 | ||
| enlarged heart | 1 supporting dataset | Wnt3aem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased circulating triglyceride level | 1 supporting dataset | Wnt3aem1(IMPC)Ccpcz | heterozygote | Early adult | 6.31x10-6 | ||
| abnormal vertebrae morphology | 1 supporting dataset | Wnt3aem1(IMPC)Ccpcz | heterozygote | Early adult | 3.78x10-6 |
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Human diseases caused by Wnt3a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Wnt3a.
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| Wnt3aem1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Wnt3atm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Wnt3atm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Wnt3atm286(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Wnt3atm286(L1L2_st2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |