Wnt1 | wingless-type MMTV integration site family, member 1

GeneMGI:98953Synonyms: Int-1, Wnt-1

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Mortality/aging

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

5Associated diseases

Expression examined in:73Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Wnt1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating creatinine level	1 supporting dataset	Wnt1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.62x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Wnt1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating cholesterol level	1 supporting dataset	Wnt1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.56x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Wnt1.

Associated images

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Histopathology

There is no histopathology data found for Wnt1.

IMPC related publications

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External links

No external links available for Wnt1.

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*Wnt1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Wnt1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Wnt1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Wnt1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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