Vldlr | very low density lipoprotein receptor

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Immune system Hematopoietic system Behavior/neurological

17 No significant impact

4 Not tested

Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal behavior1 supporting datasetVldlrem1(IMPC)MbphomozygoteEarly adult1.96x10-7 
decreased thigmotaxis2 supporting datasetsVldlrem1(IMPC)MbphomozygoteEarly adult1.92x10-7 
decreased anxiety-related response1 supporting datasetVldlrem1(IMPC)MbphomozygoteEarly adult1.88x10-8 
hyperactivity4 supporting datasetsVldlrem1(IMPC)MbphomozygoteEarly adult1.42x10-11 
abnormal spleen morphology1 supporting datasetVldlrem1(IMPC)MbphomozygoteEarly adultN/A * 
increased exploration in new environment1 supporting datasetVldlrem1(IMPC)MbphomozygoteEarly adult2.77x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Vldlrem1(IMPC)MbpExon Deletionmouse
Vldlrtm199160(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Vldlrtm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Vldlrtm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Vldlrtm270541(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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