Tuba1a | tubulin, alpha 1A
Physiological systems
16 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Mortality/aging Craniofacial Cardiovascular system
10 No significant impact
8 Not tested
Data collections
Gene metrics:5Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Tuba1aem1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Tuba1aem1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Tuba1aem1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| abnormal facial morphology | 1 supporting dataset | Tuba1aem1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| edema | 1 supporting dataset | Tuba1aem1(IMPC)Bay | homozygote | E18.5 | N/A * |
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Human diseases caused by Tuba1a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tuba1a.
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| Tuba1aem1(IMPC)Bay | Inter-exon deletion | | mouse |
| Tuba1atm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Tuba1atm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Tuba1atm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |