Trp53 | transformation related protein 53

GeneMGI:98834Synonyms: p53, p44

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

31Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



persistence of hyaloid vascular system	1 supporting dataset	Trp53^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.52x10^-7
preweaning lethality, incomplete penetrance	1 supporting dataset	Trp53^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased circulating creatine kinase level	1 supporting dataset	Trp53^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.75x10^-5
increased startle reflex	1 supporting dataset	Trp53^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.65x10^-12
abnormal retina morphology	1 supporting dataset	Trp53^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.88x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Trp53.

Associated images

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Histopathology

There is no histopathology data found for Trp53.

IMPC related publications

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External links

No external links available for Trp53.

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*Trp53^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Trp53^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Trp53^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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