Trp53 | transformation related protein 53
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging
13 No significant impact
7 Not tested
Data collections
Gene metrics:5Significant phenotypes
31Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| persistence of hyaloid vascular system | 1 supporting dataset | Trp53tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.52x10-7 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Trp53tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased circulating creatine kinase level | 1 supporting dataset | Trp53tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.75x10-5 | ||
| increased startle reflex | 1 supporting dataset | Trp53tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.65x10-12 | ||
| abnormal retina morphology | 1 supporting dataset | Trp53tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.88x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Trp53 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Trp53.
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| Trp53tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Trp53tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Trp53tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |