Trh | thyrotropin releasing hormone

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Digestive/alimentary Behavior/neurological Skeleton Cardiovascular system Renal/urinary system

13 No significant impact

5 Not tested

Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased locomotor activity4 supporting datasetsTrhem1(IMPC)TcphomozygoteEarly adult4.63x10-5 
abnormal stomach morphology1 supporting datasetTrhem1(IMPC)TcphomozygoteEarly adultN/A * 
decreased exploration in new environment1 supporting datasetTrhem1(IMPC)TcphomozygoteEarly adult7.44x10-5 
increased circulating cholesterol level1 supporting datasetTrhem1(IMPC)TcphomozygoteEarly adult1.63x10-13 
increased bone mineral density1 supporting datasetTrhem1(IMPC)TcphomozygoteEarly adult2.97x10-7 
small heart1 supporting datasetTrhem1(IMPC)TcphomozygoteEarly adultN/A * 
increased circulating HDL cholesterol level1 supporting datasetTrhem1(IMPC)TcphomozygoteEarly adult9.19x10-9 
decreased heart rate1 supporting datasetTrhem1(IMPC)TcphomozygoteEarly adult7.24x10-6 
increased bone mineral content1 supporting datasetTrhem1(IMPC)TcphomozygoteEarly adult5.92x10-8 
decreased heart weight1 supporting datasetTrhem1(IMPC)TcphomozygoteEarly adult1.19x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Trhem1(IMPC)TcpInter-exon deletionmouse
Trhtm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell

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