Trh | thyrotropin releasing hormone
GeneMGI:98823
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Digestive/alimentary Behavior/neurological Skeleton Cardiovascular system Renal/urinary system
13 No significant impact
5 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased locomotor activity | 4 supporting datasets | Trhem1(IMPC)Tcp | homozygote | Early adult | 4.63x10-5 | ||
| abnormal stomach morphology | 1 supporting dataset | Trhem1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| decreased exploration in new environment | 1 supporting dataset | Trhem1(IMPC)Tcp | homozygote | Early adult | 7.44x10-5 | ||
| increased circulating cholesterol level | 1 supporting dataset | Trhem1(IMPC)Tcp | homozygote | Early adult | 1.63x10-13 | ||
| increased bone mineral density | 1 supporting dataset | Trhem1(IMPC)Tcp | homozygote | Early adult | 2.97x10-7 | ||
| small heart | 1 supporting dataset | Trhem1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Trhem1(IMPC)Tcp | homozygote | Early adult | 9.19x10-9 | ||
| decreased heart rate | 1 supporting dataset | Trhem1(IMPC)Tcp | homozygote | Early adult | 7.24x10-6 | ||
| increased bone mineral content | 1 supporting dataset | Trhem1(IMPC)Tcp | homozygote | Early adult | 5.92x10-8 | ||
| decreased heart weight | 1 supporting dataset | Trhem1(IMPC)Tcp | homozygote | Early adult | 1.19x10-5 |
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Human diseases caused by Trh mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Trh.
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