Tpm1 | tropomyosin 1, alpha
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Nervous system Behavior/neurological Cardiovascular system Mortality/aging
13 No significant impact
5 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:9Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased prepulse inhibition | 2 supporting datasets | Tpm1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.48x10-5 | ||
| increased startle reflex | 2 supporting datasets | Tpm1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 8.71x10-7 | ||
| decreased body weight | 1 supporting dataset | Tpm1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.72x10-5 | ||
| increased blood uric acid level | 1 supporting dataset | Tpm1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 4.59x10-6 | ||
| increased heart weight | 1 supporting dataset | Tpm1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.51x10-8 | ||
| increased circulating creatine kinase level | 1 supporting dataset | Tpm1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.31x10-5 | ||
| increased circulating creatinine level | 1 supporting dataset | Tpm1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 4.16x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Tpm1tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal glucose homeostasis | 1 supporting dataset | Tpm1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.66x10-7 |
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Human diseases caused by Tpm1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tpm1.
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| Tpm1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Tpm1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tpm1tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |