Tpm1 | tropomyosin 1, alpha

GeneMGI:98809Synonyms: TM2, Tm3, +2 more

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Nervous system Behavior/neurological Cardiovascular system Mortality/aging

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased prepulse inhibition	2 supporting datasets	Tpm1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.48x10^-5
increased startle reflex	2 supporting datasets	Tpm1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	8.71x10^-7
decreased body weight	1 supporting dataset	Tpm1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.72x10^-5
increased blood uric acid level	1 supporting dataset	Tpm1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.59x10^-6
increased heart weight	1 supporting dataset	Tpm1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.51x10^-8
increased circulating creatine kinase level	1 supporting dataset	Tpm1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	7.31x10^-5
increased circulating creatinine level	1 supporting dataset	Tpm1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.16x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Tpm1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal glucose homeostasis	1 supporting dataset	Tpm1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.66x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tpm1.

Associated images

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Histopathology

There is no histopathology data found for Tpm1.

IMPC related publications

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External links

No external links available for Tpm1.

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*Tpm1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Tpm1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tpm1^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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