Tnnc1 | troponin C, cardiac/slow skeletal
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Embryo Growth/size/body region Behavior/neurological Mortality/aging
16 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Tnnc1em1(IMPC)J | homozygote | E15.5 | N/A * | ||
| limb grasping | 1 supporting dataset | Tnnc1em1(IMPC)J | heterozygote | Late adult | 9x10-5 | ||
| abnormal embryo size | 1 supporting dataset | Tnnc1em1(IMPC)J | heterozygote | E15.5 | N/A * | ||
| impaired righting response | 1 supporting dataset | Tnnc1em1(IMPC)J | heterozygote | Late adult | 2.35x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Tnnc1em1(IMPC)J | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Tnnc1em1(IMPC)J | homozygote | E12.5 | N/A * |
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Human diseases caused by Tnnc1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tnnc1.
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| Tnnc1em1(IMPC)J | Exon Deletion | | mouse |
| Tnnc1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Tnnc1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |