Tgfb3 | transforming growth factor, beta 3
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Mortality/aging
16 No significant impact
4 Not tested
Gene metrics:3Significant phenotypes
7Associated diseases
Expression examined in:41Adult tissues
29Embryo tissues
| preweaning lethality, complete penetrance | 2 supporting datasets | Tgfb3tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Tgfb3tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| abnormal testis morphology | 1 supporting dataset | Tgfb3tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
| eye | heterozygote | Section images | 100% (2/2) | 0% (0/335) |
| heart | heterozygote | n/a | 0% (0/2) | 0.36% (2/550) |
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Tgfb3.
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| Tgfb3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Tgfb3tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Tgfb3tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Tgfb3tm449986(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |