Tek | TEK receptor tyrosine kinase

GeneMGI:98664Synonyms: Tie2, Hyk, +2 more

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Cardiovascular system Mortality/aging

18 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

5Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Phy. System:

Life Stage:



embryonic lethality prior to tooth bud stage	1 supporting dataset	Tek^{tm1b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*
abnormal pericardium morphology	1 supporting dataset	Tek^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Tek^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tek.

Associated images

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Histopathology

There is no histopathology data found for Tek.

IMPC related publications

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External links

No external links available for Tek.

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*Tek^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tek^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tek^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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