Dntt | deoxynucleotidyltransferase, terminal
Physiological systems
18 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological
16 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| increased circulating sodium level | 1 supporting dataset | Dntttm2b(KOMP)Wtsi | homozygote | Early adult | 2.51x10-7 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Dntttm2b(KOMP)Wtsi | homozygote | Early adult | 8.09x10-9 | ||
| increased circulating cholesterol level | 1 supporting dataset | Dntttm2b(KOMP)Wtsi | homozygote | Early adult | 1.58x10-7 | ||
| increased coping response | 1 supporting dataset | Dntttm2b(KOMP)Wtsi | homozygote | Early adult | 7.55x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Dntt mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dntt.
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| Dntttm119376(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Dntttm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Dntttm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dntttm2b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dntttm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |