Dntt | deoxynucleotidyltransferase, terminal

GeneMGI:98659Synonyms: Tdt

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological

16 No significant impact

6 Not tested

Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues

Phenotypes

increased circulating sodium level1 supporting datasetDntttm2b(KOMP)WtsihomozygoteEarly adult2.51x10-7 
increased circulating HDL cholesterol level1 supporting datasetDntttm2b(KOMP)WtsihomozygoteEarly adult8.09x10-9 
increased circulating cholesterol level1 supporting datasetDntttm2b(KOMP)WtsihomozygoteEarly adult1.58x10-7 
increased coping response1 supporting datasetDntttm2b(KOMP)WtsihomozygoteEarly adult7.55x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
brainheterozygoten/a0% (0/2)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
epididymisheterozygoten/a0% (0/1)87.5% (21/24)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Human diseases caused by Dntt mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Dntttm119376(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Dntttm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Dntttm2a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Dntttm2b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Dntttm2e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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