Ubtf | upstream binding transcription factor, RNA polymerase I

GeneMGI:98512Synonyms: UBF1, UBF, +2 more

Physiological systems

22 / 24 physiological systems tested

15 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Embryo Nervous system Vision/eye Liver/biliary system Behavior/neurological Mortality/aging

7 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:27Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Ubtf^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged epididymis	1 supporting dataset	Ubtf^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Ubtf^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal seminal vesicle morphology	1 supporting dataset	Ubtf^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal embryo turning	1 supporting dataset	Ubtf^em1(IMPC)Mbp	heterozygote	E9.5	N/A ^*
enlarged kidney	1 supporting dataset	Ubtf^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Ubtf^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal adrenal gland morphology	1 supporting dataset	Ubtf^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal skin morphology	2 supporting datasets	Ubtf^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Ubtf^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ubtf.

Associated images

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Histopathology

There is no histopathology data found for Ubtf.

IMPC related publications

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External links

No external links available for Ubtf.

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*Ubtf^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Ubtf^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ubtf^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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