Tcf4 | transcription factor 4
Physiological systems
17 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Vision/eye Mortality/aging
15 No significant impact
7 Not tested
Data collections
Gene metrics:2Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal retina morphology | 1 supporting dataset | Tcf4tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 4.58x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Tcf4tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
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Human diseases caused by Tcf4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Tcf4.
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| Tcf4tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tcf4tm1c(EUCOMM)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Tcf4tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |