Tat | tyrosine aminotransferase

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



prolonged RR interval	1 supporting dataset	Tat^em1(IMPC)J	homozygote	Late adult	1.92x10^-6
hyperactivity	6 supporting datasets	Tat^em1(IMPC)J	homozygote	Early adult	3.18x10^-7
decreased total body fat amount	1 supporting dataset	Tat^em1(IMPC)J	homozygote	Late adult	5.09x10^-5
increased lean body mass	1 supporting dataset	Tat^em1(IMPC)J	homozygote	Late adult	3.21x10^-5
increased grip strength	1 supporting dataset	Tat^em1(IMPC)J	homozygote	Late adult	1.59x10^-7
persistence of hyaloid vascular system	1 supporting dataset	Tat^em1(IMPC)J	homozygote	Late adult	5.4x10^-6
preweaning lethality, incomplete penetrance	1 supporting dataset	Tat^em1(IMPC)J	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Tat^em1(IMPC)J	homozygote	Late adult	6.21x10^-5
abnormal retina blood vessel morphology	1 supporting dataset	Tat^em1(IMPC)J	homozygote	Late adult	2.59x10^-5
decreased heart rate	1 supporting dataset	Tat^em1(IMPC)J	homozygote	Late adult	3.54x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tat.

Associated images

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Histopathology

There is no histopathology data found for Tat.

IMPC related publications

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External links

No external links available for Tat.

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*Tat^em1(IMPC)J*	Exon Deletion	‌	mouse
*Tat^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tat^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Tat^{tm44693(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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