Sox4 | SRY (sex determining region Y)-box 4

GeneMGI:98366Synonyms: Sox-4

Physiological systems

21 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Embryo Growth/size/body region Nervous system Vision/eye Liver/biliary system Behavior/neurological Skeleton Cardiovascular system Mortality/aging

9 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal neural tube morphology	1 supporting dataset	Sox4^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal heart morphology	1 supporting dataset	Sox4^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Sox4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged uterus	1 supporting dataset	Sox4^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal gallbladder morphology	1 supporting dataset	Sox4^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal retina vasculature morphology	1 supporting dataset	Sox4^em1(IMPC)Mbp	heterozygote	Early adult	2.44x10^-6
decreased body length	1 supporting dataset	Sox4^em1(IMPC)Mbp	heterozygote	Early adult	2.63x10^-9
abnormal bone structure	1 supporting dataset	Sox4^em1(IMPC)Mbp	heterozygote	Early adult	8.97x10^-5
abnormal brain morphology	1 supporting dataset	Sox4^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Sox4^em1(IMPC)Mbp	heterozygote	Early adult	2.39x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Sox4.

Associated images

Loading...

Histopathology

There is no histopathology data found for Sox4.

IMPC related publications

Loading...

External links

No external links available for Sox4.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Sox4^em1(IMPC)Mbp*	Whole-gene deletion	‌	mouse
*Sox4^{tm456048(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes