Sox2 | SRY (sex determining region Y)-box 2
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Cardiovascular system Mortality/aging
14 No significant impact
3 Not tested
Data collections
Gene metrics:11Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Sox2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal brain morphology | 1 supporting dataset | Sox2em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Sox2em1(IMPC)Mbp | heterozygote | Early adult | 9.42x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Sox2em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| irregularly shaped pupil | 1 supporting dataset | Sox2em1(IMPC)Mbp | heterozygote | Early adult | 2.83x10-6 | ||
| abnormal optic disk morphology | 1 supporting dataset | Sox2em1(IMPC)Mbp | heterozygote | Early adult | 6.44x10-9 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Sox2em1(IMPC)Mbp | heterozygote | Early adult | 7.68x10-5 | ||
| embryonic growth retardation | 1 supporting dataset | Sox2em1(IMPC)Mbp | heterozygote | E9.5 | N/A * | ||
| enhanced contextual conditioning behavior | 1 supporting dataset | Sox2em1(IMPC)Mbp | heterozygote | Early adult | 3x10-8 |
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External links
No external links available for Sox2.
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| Sox2em1(IMPC)Mbp | Whole-gene deletion | | mouse |
| Sox2tm400582(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |