Shh | sonic hedgehog

GeneMGI:98297Synonyms: Hhg1

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Behavior/neurological Skeleton Mortality/aging

16 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

16Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



decreased bone mineral content	2 supporting datasets	Shh^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.24x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Shh^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating HDL cholesterol level	1 supporting dataset	Shh^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.27x10^-7
limb grasping	1 supporting dataset	Shh^tm1Chg	heterozygote	Early adult	5.19x10^-5
increased startle reflex	4 supporting datasets	Shh^tm1Chg	heterozygote	Early adult	4.41x10^-8
preweaning lethality, complete penetrance	1 supporting dataset	Shh^tm1Chg	homozygote	Early adult	N/A ^*
decreased lean body mass	2 supporting datasets	Shh^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.08x10^-8
increased total body fat amount	2 supporting datasets	Shh^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.29x10^-9
impaired glucose tolerance	1 supporting dataset	Shh^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.7x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Shh.

Associated images

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Histopathology

There is no histopathology data found for Shh.

IMPC related publications

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External links

No external links available for Shh.

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*Shh^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Shh^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Shh^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Shh^{tm39984(L1L2_st0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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