Shh | sonic hedgehog
Physiological systems
22 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Behavior/neurological Skeleton Mortality/aging
16 No significant impact
2 Not tested
Gene metrics:8Significant phenotypes
16Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased bone mineral content | 2 supporting datasets | Shhtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.24x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Shhtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Shhtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.27x10-7 | ||
| limb grasping | 1 supporting dataset | Shhtm1Chg | heterozygote | Early adult | 5.19x10-5 | ||
| increased startle reflex | 4 supporting datasets | Shhtm1Chg | heterozygote | Early adult | 4.41x10-8 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Shhtm1Chg | homozygote | Early adult | N/A * | ||
| decreased lean body mass | 2 supporting datasets | Shhtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.08x10-8 | ||
| increased total body fat amount | 2 supporting datasets | Shhtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.29x10-9 | ||
| impaired glucose tolerance | 1 supporting dataset | Shhtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.7x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (1/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Shh mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Shh.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Shhtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Shhtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Shhtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Shhtm39984(L1L2_st0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |