Scn4a | sodium channel, voltage-gated, type IV, alpha

GeneMGI:98250Synonyms: Nav1.4, SkM1, +1 more

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Mortality/aging

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

14Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased circulating alkaline phosphatase level	1 supporting dataset	Scn4a^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	1.27x10^-6
increased circulating amylase level	1 supporting dataset	Scn4a^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	6.51x10^-29
decreased mean platelet volume	1 supporting dataset	Scn4a^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	9.09x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Scn4a^{tm2b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Scn4a.

Associated images

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Histopathology

There is no histopathology data found for Scn4a.

IMPC related publications

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External links

No external links available for Scn4a.

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*Scn4a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Scn4a^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Scn4a^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Scn4a^{tm2b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Scn4a^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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