Rrm2 | ribonucleotide reductase M2
Physiological systems
20 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Mortality/aging
18 No significant impact
4 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
62Embryo tissues
| embryonic lethality prior to organogenesis | 1 supporting dataset | Rrm2tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| increased circulating phosphate level | 1 supporting dataset | Rrm2tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.53x10-6 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Rrm2tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Rrm2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Rrm2.
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| Rrm2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rrm2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rrm2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |