Rpe65 | retinal pigment epithelium 65

GeneMGI:98001Synonyms: A930029L06Rik, Mord1, +1 more

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Vision/eye Behavior/neurological

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



impaired pupillary reflex	1 supporting dataset	Rpe65^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	4.34x10^-18
increased startle reflex	1 supporting dataset	Rpe65^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	6.52x10^-8
limb grasping	1 supporting dataset	Rpe65^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	4.11x10^-8
abnormal behavior	2 supporting datasets	Rpe65^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.59x10^-6
abnormal pupil morphology	1 supporting dataset	Rpe65^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.03x10^-5
abnormal retina morphology	2 supporting datasets	Rpe65^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.09x10^-15

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rpe65.

Associated images

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Histopathology

There is no histopathology data found for Rpe65.

IMPC related publications

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External links

No external links available for Rpe65.

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*Rpe65^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rpe65^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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