Rnps1 | RNA binding protein with serine rich domain 1
GeneMGI:97960
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system
12 No significant impact
6 Not tested
Data collections
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating alanine transaminase level | 1 supporting dataset | Rnps1em1(IMPC)Hmgu | heterozygote | Early adult | 3.3x10-5 | ||
| abnormal vitreous body morphology | 1 supporting dataset | Rnps1em1(IMPC)Hmgu | heterozygote | Early adult | 7.87x10-5 | ||
| abnormal iris morphology | 1 supporting dataset | Rnps1em1(IMPC)Hmgu | heterozygote | Early adult | 4.06x10-9 | ||
| irregularly shaped pupil | 1 supporting dataset | Rnps1em1(IMPC)Hmgu | heterozygote | Early adult | 9.96x10-8 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Rnps1em1(IMPC)Hmgu | heterozygote | Early adult | 8.13x10-5 | ||
| increased mean corpuscular volume | 1 supporting dataset | Rnps1em1(IMPC)Hmgu | heterozygote | Early adult | 2x10-6 | ||
| increased startle reflex | 1 supporting dataset | Rnps1em1(IMPC)Hmgu | heterozygote | Early adult | 5.14x10-7 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Rnps1em1(IMPC)Hmgu | heterozygote | Early adult | 4.88x10-5 | ||
| abnormal cornea morphology | 1 supporting dataset | Rnps1em1(IMPC)Hmgu | heterozygote | Early adult | 1.15x10-5 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Rnps1em1(IMPC)Hmgu | heterozygote | Early adult | 3.43x10-6 |
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Human diseases caused by Rnps1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rnps1.
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| Rnps1em1(IMPC)Hmgu | Exon Deletion | | mouse |
| Rnps1tm188337(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Rnps1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |