Rfc1 | replication factor C (activator 1) 1

GeneMGI:97891Synonyms: RFC140, 140kDa, +2 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Hematopoietic system Mortality/aging

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:51Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased circulating cholesterol level	2 supporting datasets	Rfc1^{tm1b(KOMP)Mbp}	heterozygote	Early adult	6.46x10^-5
abnormal embryo size	1 supporting dataset	Rfc1^{tm1b(KOMP)Mbp}	heterozygote	E9.5	N/A ^*
abnormal embryo turning	1 supporting dataset	Rfc1^{tm1b(KOMP)Mbp}	heterozygote	E9.5	N/A ^*
increased circulating HDL cholesterol level	1 supporting dataset	Rfc1^{tm1b(KOMP)Mbp}	heterozygote	Early adult	1.35x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Rfc1^{tm1b(KOMP)Mbp}	homozygote	Early adult	N/A ^*
embryonic growth retardation	1 supporting dataset	Rfc1^{tm1b(KOMP)Mbp}	heterozygote	E9.5	N/A ^*
decreased circulating free fatty acids level	1 supporting dataset	Rfc1^{tm1b(KOMP)Mbp}	heterozygote	Early adult	8.44x10^-5
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Rfc1^{tm1b(KOMP)Mbp}	heterozygote	Early adult	8.46x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Rfc1^{tm1b(KOMP)Mbp}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rfc1.

Associated images

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Histopathology

There is no histopathology data found for Rfc1.

IMPC related publications

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External links

No external links available for Rfc1.

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*Rfc1^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rfc1^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rfc1^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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