Rasa1 | RAS p21 protein activator 1

GeneMGI:97860Synonyms: p120-rasGAP, Gap

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

4Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic lethality prior to tooth bud stage	1 supporting dataset	Rasa1^{tm1b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*
thrombocytopenia	1 supporting dataset	Rasa1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.18x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Rasa1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.5x10^-5
increased heart weight	1 supporting dataset	Rasa1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.92x10^-6
decreased circulating glucose level	1 supporting dataset	Rasa1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.15x10^-6
abnormal behavior	1 supporting dataset	Rasa1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.35x10^-5
decreased circulating phosphate level	1 supporting dataset	Rasa1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.17x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Rasa1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Rasa1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.38x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rasa1.

Associated images

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Histopathology

There is no histopathology data found for Rasa1.

IMPC related publications

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External links

No external links available for Rasa1.

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*Rasa1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rasa1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rasa1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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