Ptprd | protein tyrosine phosphatase receptor type D

GeneMGI:97812Synonyms: 1110002J03Rik, B230219D21Rik, +1 more

Physiological systems

18 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Mortality/aging

10 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased grip strength	3 supporting datasets	Ptprd^{tm2a(KOMP)Wtsi}	homozygote	Early adult	9.02x10^-8
decreased total body fat amount	1 supporting dataset	Ptprd^{tm2a(KOMP)Wtsi}	homozygote	Early adult	6.94x10^-5
improved glucose tolerance	1 supporting dataset	Ptprd^{tm2a(KOMP)Wtsi}	homozygote	Early adult	2.25x10^-5
increased leukocyte cell number	1 supporting dataset	Ptprd^{tm2a(KOMP)Wtsi}	homozygote	Early adult	6.54x10^-6
increased lean body mass	2 supporting datasets	Ptprd^{tm2a(KOMP)Wtsi}	homozygote	Early adult	2.67x10^-5
increased circulating iron level	1 supporting dataset	Ptprd^{tm2a(KOMP)Wtsi}	homozygote	Early adult	1.92x10^-5
increased bone mineral content	1 supporting dataset	Ptprd^{tm2a(KOMP)Wtsi}	homozygote	Early adult	7.24x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Ptprd^{tm2a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ptprd.

Associated images

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Histopathology

There is no histopathology data found for Ptprd.

IMPC related publications

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External links

No external links available for Ptprd.

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*Ptprd^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Ptprd^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ptprd^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Ptprd^{tm470565(L1L2_GT0_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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