Ptpra | protein tyrosine phosphatase receptor type A

GeneMGI:97808Synonyms: PTPalpha, RPTPalpha, +3 more

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Nervous system Hematopoietic system Behavior/neurological

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased startle reflex1 supporting datasetPtpratm1b(EUCOMM)HmguhomozygoteEarly adult1.14x10-7 
increased mean corpuscular hemoglobin1 supporting datasetPtpratm1b(EUCOMM)HmguhomozygoteEarly adult6.99x10-5 
decreased prepulse inhibition2 supporting datasetsPtpratm1b(EUCOMM)HmguhomozygoteEarly adult9.86x10-6 
decreased grip strength1 supporting datasetPtpratm1b(EUCOMM)HmguhomozygoteEarly adult4.77x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ptpratm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Ptpratm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Ptpratm28617(L1L2_gt1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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