Psph | phosphoserine phosphatase

GeneMGI:97788Synonyms: PSPase

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Endocrine/exocrine gland Integument Embryo Growth/size/body region Vision/eye Hematopoietic system Mortality/aging Craniofacial Cardiovascular system

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

3Associated diseases

Expression examined in:42Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



thrombocytopenia	1 supporting dataset	Psph^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.62x10^-5
decreased circulating triglyceride level	1 supporting dataset	Psph^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	9.53x10^-5
anophthalmia	1 supporting dataset	Psph^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
increased heart rate variability	1 supporting dataset	Psph^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	4.96x10^-5
pale yolk sac	1 supporting dataset	Psph^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
pale placenta	1 supporting dataset	Psph^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
small adrenal glands	1 supporting dataset	Psph^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
cardiovascular system phenotype	1 supporting dataset	Psph^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	8.75x10^-5
abnormal embryo size	1 supporting dataset	Psph^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
abnormal heart morphology	1 supporting dataset	Psph^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Psph.

Associated images

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Histopathology

There is no histopathology data found for Psph.

IMPC related publications

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External links

No external links available for Psph.

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*Psph^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Psph^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Psph^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Psph^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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