Ctsa | cathepsin A

GeneMGI:97748Synonyms: PPCA, Ppgb

Physiological systems

17 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

8 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:38Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating alkaline phosphatase level	1 supporting dataset	Ctsa^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	8.82x10^-13
tremors	1 supporting dataset	Ctsa^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	2.4x10^-15
decreased circulating calcium level	1 supporting dataset	Ctsa^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	1.56x10^-6
decreased erythrocyte cell number	1 supporting dataset	Ctsa^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	6.42x10^-10
increased circulating aspartate transaminase level	1 supporting dataset	Ctsa^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	5.17x10^-20
decreased circulating HDL cholesterol level	1 supporting dataset	Ctsa^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	3.8x10^-7
narrow eye opening	1 supporting dataset	Ctsa^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	7.46x10^-11
increased freezing behavior	2 supporting datasets	Ctsa^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	9.09x10^-12
increased circulating iron level	1 supporting dataset	Ctsa^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	4.28x10^-8
increased spleen weight	1 supporting dataset	Ctsa^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	9.03x10^-35

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ctsa.

Associated images

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Histopathology

There is no histopathology data found for Ctsa.

IMPC related publications

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External links

No external links available for Ctsa.

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*Ctsa^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ctsa^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Ctsa^{tm29429(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Ctsa^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ctsa^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ctsa^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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