Pparg | peroxisome proliferator activated receptor gamma

GeneMGI:97747Synonyms: Ppar-gamma2, PPARgamma2, +3 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Behavior/neurological Mortality/aging

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

9Associated diseases

Expression examined in:46Adult tissues

21Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased lean body mass	1 supporting dataset	Pparg^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.29x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Pparg^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased fasting circulating glucose level	1 supporting dataset	Pparg^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	9.7x10^-5
abnormal gait	1 supporting dataset	Pparg^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.45x10^-8
embryonic lethality prior to tooth bud stage	1 supporting dataset	Pparg^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
increased total body fat amount	1 supporting dataset	Pparg^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.46x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pparg.

Associated images

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Histopathology

There is no histopathology data found for Pparg.

IMPC related publications

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External links

No external links available for Pparg.

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*Pparg^{tm119150(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Pparg^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pparg^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pparg^{tm1c(KOMP)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Pparg^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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