Plcb1 | phospholipase C, beta 1
Physiological systems
19 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Renal/urinary system
9 No significant impact
5 Not tested
Data collections
Gene metrics:16Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged spleen | 1 supporting dataset | Plcb1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal liver morphology | 1 supporting dataset | Plcb1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Plcb1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| hyperactivity | 4 supporting datasets | Plcb1em1(IMPC)Mbp | heterozygote | Early adult | 1.06x10-13 | ||
| cataract | 1 supporting dataset | Plcb1em1(IMPC)Mbp | heterozygote | Late adult | 3.08x10-6 | ||
| enlarged spleen | 2 supporting datasets | Plcb1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal lymph node morphology | 2 supporting datasets | Plcb1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| enlarged kidney | 1 supporting dataset | Plcb1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Plcb1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| microphthalmia | 1 supporting dataset | Plcb1em1(IMPC)Mbp | heterozygote | Late adult | N/A * |
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Human diseases caused by Plcb1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Plcb1.
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| Plcb1em1(IMPC)Mbp | Exon Deletion | | mouse |
| Plcb1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Plcb1tm42685(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |