Plau | plasminogen activator, urokinase

GeneMGI:97611Synonyms: uPA, u-PA, +1 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Immune system Hematopoietic system Behavior/neurological

16 No significant impact

5 Not tested

Gene metrics:4Significant phenotypes
3Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

increased neutrophil cell number1 supporting datasetPlautm1b(EUCOMM)WtsihomozygoteEarly adult9.65x10-5 
increased monocyte cell number1 supporting datasetPlautm1b(EUCOMM)WtsihomozygoteEarly adult9.58x10-5 
decreased exploration in new environment1 supporting datasetPlautm1b(EUCOMM)WtsihomozygoteEarly adult3.85x10-5 
decreased grip strength1 supporting datasetPlautm1b(EUCOMM)WtsihomozygoteEarly adult2.01x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Plautm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
Plautm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
es cell
Plautm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Plautm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Plautm1e(EUCOMM)WtsiTargeted, non-conditional allelees cell

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