Phkb | phosphorylase kinase beta

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Adipose tissue Growth/size/body region Vision/eye Behavior/neurological Mortality/aging

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased total body fat amount	2 supporting datasets	Phkb^em1(IMPC)J	heterozygote	Early adult	2.24x10^-6
limb grasping	1 supporting dataset	Phkb^em1(IMPC)J	heterozygote	Late adult	1.5x10^-7
increased circulating alanine transaminase level	1 supporting dataset	Phkb^em1(IMPC)J	homozygote	Late adult	6.27x10^-8
decreased lean body mass	1 supporting dataset	Phkb^em1(IMPC)J	heterozygote	Early adult	5.6x10^-5
abnormal coat/hair pigmentation	1 supporting dataset	Phkb^em1(IMPC)J	heterozygote	Late adult	2.42x10^-5
impaired righting response	1 supporting dataset	Phkb^em1(IMPC)J	heterozygote	Late adult	1.03x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Phkb^em1(IMPC)J	homozygote	Late adult	4.62x10^-5
abnormal lens morphology	1 supporting dataset	Phkb^em1(IMPC)J	heterozygote	Late adult	9.63x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Phkb^em1(IMPC)J	homozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Phkb^em1(IMPC)J	homozygote	Late adult	3.84x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Phkb.

Associated images

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Histopathology

There is no histopathology data found for Phkb.

IMPC related publications

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External links

No external links available for Phkb.

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*Phkb^em1(IMPC)J*	Exon Deletion	‌	mouse
*Phkb^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Phkb^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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