Phb1 | prohibitin 1

GeneMGI:97572Synonyms: Phb

Physiological systems

16 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Mortality/aging

12 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Phb1^em1(IMPC)H	homozygote	Early adult	N/A ^*
increased blood urea nitrogen level	1 supporting dataset	Phb1^em1(IMPC)H	heterozygote	Early adult	4.5x10^-7
increased circulating triglyceride level	1 supporting dataset	Phb1^em1(IMPC)H	heterozygote	Early adult	1.68x10^-5
decreased circulating potassium level	1 supporting dataset	Phb1^em1(IMPC)H	heterozygote	Early adult	6.44x10^-5
increased large unstained cell number	1 supporting dataset	Phb1^em1(IMPC)H	heterozygote	Early adult	6.73x10^-5
decreased red blood cell distribution width	1 supporting dataset	Phb1^em1(IMPC)H	heterozygote	Early adult	8.08x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Phb1.

Associated images

Loading...

Histopathology

There is no histopathology data found for Phb1.

IMPC related publications

Loading...

External links

No external links available for Phb1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Phb1^em1(IMPC)H*	Exon Deletion	‌	mouse
*Phb1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Phb1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Phb1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Phb1^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Phb1^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes