Abcb4 | ATP-binding cassette, sub-family B member 4

GeneMGI:97569Synonyms: Pgy2, mdr-2, +2 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



decreased locomotor activity	1 supporting dataset	Abcb4^tm1Bor	homozygote	Early adult	9.74x10^-6
increased circulating potassium level	1 supporting dataset	Abcb4^em1(IMPC)H	homozygote	Early adult	6.14x10^-6
increased lymphocyte cell number	1 supporting dataset	Abcb4^em1(IMPC)H	homozygote	Early adult	8.21x10^-6
increased startle reflex	6 supporting datasets	Abcb4^tm1Bor	homozygote	Early adult	2.57x10^-9
increased circulating creatinine level	1 supporting dataset	Abcb4^em1(IMPC)H	homozygote	Early adult	1.15x10^-5
decreased mean corpuscular hemoglobin	1 supporting dataset	Abcb4^em1(IMPC)H	homozygote	Early adult	5.78x10^-14
increased circulating aspartate transaminase level	1 supporting dataset	Abcb4^em1(IMPC)H	homozygote	Early adult	1.31x10^-292
increased basophil cell number	1 supporting dataset	Abcb4^em1(IMPC)H	homozygote	Early adult	5.49x10^-5
increased circulating amylase level	1 supporting dataset	Abcb4^em1(IMPC)H	homozygote	Early adult	6.64x10^-5
increased spleen weight	1 supporting dataset	Abcb4^em1(IMPC)H	homozygote	Early adult	7.78x10^-13

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Abcb4.

Associated images

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Histopathology

There is no histopathology data found for Abcb4.

IMPC related publications

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External links

No external links available for Abcb4.

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*Abcb4^em1(IMPC)H*	Exon Deletion	‌	mouse
*Abcb4^em2(IMPC)H*	Exon Deletion	‌	mouse
*Abcb4^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Abcb4^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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