Pfkm | phosphofructokinase, muscle

GeneMGI:97548Synonyms: Pfk4, PFK-A, +3 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Vision/eye Liver/biliary system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



enlarged testis	1 supporting dataset	Pfkm^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
decreased total body fat amount	1 supporting dataset	Pfkm^em1(IMPC)Mbp	heterozygote	Early adult	4.69x10^-5
small seminal vesicle	1 supporting dataset	Pfkm^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
increased lean body mass	1 supporting dataset	Pfkm^em1(IMPC)Mbp	heterozygote	Early adult	1.95x10^-5
abnormal skin morphology	1 supporting dataset	Pfkm^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Pfkm^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
decreased body length	1 supporting dataset	Pfkm^em1(IMPC)Mbp	heterozygote	Early adult	3.03x10^-5
abnormal liver morphology	1 supporting dataset	Pfkm^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal vitreous body morphology	1 supporting dataset	Pfkm^em1(IMPC)Mbp	heterozygote	Early adult	1.63x10^-5
small liver	1 supporting dataset	Pfkm^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pfkm.

Associated images

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Histopathology

There is no histopathology data found for Pfkm.

IMPC related publications

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External links

No external links available for Pfkm.

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*Pfkm^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Pfkm^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Pfkm^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pfkm^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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