Pepd | peptidase D

GeneMGI:97542Synonyms: dal, Pep4, +2 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Digestive/alimentary Nervous system Vision/eye Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:38Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:

Life Stage:



increased leukocyte cell number	1 supporting dataset	Pepd^{tm1a(KOMP)Wtsi}	homozygote	Early adult	7.9x10^-6
decreased bone mineral density	1 supporting dataset	Pepd^{tm1a(KOMP)Wtsi}	homozygote	Early adult	8.13x10^-6
decreased heart rate	1 supporting dataset	Pepd^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.23x10^-5
decreased grip strength	1 supporting dataset	Pepd^{tm1b(KOMP)Wtsi}	homozygote	Late adult	7.34x10^-5
increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number	1 supporting dataset	Pepd^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal bone structure	1 supporting dataset	Pepd^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.37x10^-8
abnormal cornea morphology	1 supporting dataset	Pepd^{tm1a(KOMP)Wtsi}	homozygote	Early adult	9.11x10^-5
prolonged RR interval	1 supporting dataset	Pepd^{tm1b(KOMP)Wtsi}	homozygote	Late adult	6.5x10^-16
decreased Ly6C-positive NK T cell number	1 supporting dataset	Pepd^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased bone mineral content	2 supporting datasets	Pepd^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.73x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pepd.

Associated images

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Histopathology

There is no histopathology data found for Pepd.

IMPC related publications

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External links

No external links available for Pepd.

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*Pepd^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Pepd^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pepd^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pepd^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Pepd^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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