Pdgfrb | platelet derived growth factor receptor, beta polypeptide

GeneMGI:97531Synonyms: CD140b, Pdgfr

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Growth/size/body region Cardiovascular system Mortality/aging

14 No significant impact

4 Not tested

Gene metrics:5Significant phenotypes
12Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

increased circulating triglyceride level1 supporting datasetPdgfrbtm1b(EUCOMM)HmguheterozygoteEarly adult5.19x10-5 
enlarged heart1 supporting datasetPdgfrbtm1b(EUCOMM)HmguheterozygoteEarly adultN/A * 
abnormal seminal vesicle morphology1 supporting datasetPdgfrbtm1b(EUCOMM)HmguheterozygoteEarly adultN/A * 
preweaning lethality, complete penetrance1 supporting datasetPdgfrbtm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
decreased circulating fructosamine level1 supporting datasetPdgfrbtm1b(EUCOMM)HmguheterozygoteEarly adult3.56x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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